The Importance of Targeted Drug Delivery Systems on Pancreatic Cancer
S. Kaleli
Sakarya University, Faculty of Medicine, Department of Medical Biology, Sakarya, Turkey
G. Güney *
Sakarya University, Faculty of Medicine, Department of Medical Biology, Sakarya, Turkey.
*Author to whom correspondence should be addressed.
Abstract
Pancreatic cancer (PC) is the fourth type of cancer-related death in the world. There is estimated 45,220 new cases of PC will be diagnosed and 38,460 people will be passed away from the disease in the near future. The absence of diagnostic and prognostic markers and also unresponsiveness to current therapies including radiation and chemotherapies are major barriers against successful therapy even in the initial stage. The current therapies is not sufficient to provide effective treatment for PC patients due torapiddrug solubility and metabolism, insufficient drug concentration at the specific site and adverse side effects. To eliminate this disadvantages, nanoparticle based drug delivery systems have been investigated.In this review, we try to reveal the genetic and molecular mechanism which cause PC and emphasize the importance of targeted drug delivery systems for the disease.
Keywords: Pancreatic Cancer (PC), drug delivery systems, cancer therapy