Genotoxicity in Neuro Degenerative and Neuropsychiatric Diseases: A Review
Chayanika Talukdar *
Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore- 560054, India.
Ashoka Babu VL
Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore- 560054, India.
*Author to whom correspondence should be addressed.
Abstract
The research investigates how genotoxicity drives the development of diseases that affect the nervous system as well neuropsychiatric conditions. This phenomenon shows that neuronal cells experience increased sensitivity to genomic harm partly because of their elevated metabolic activity together with restricted DNA repair mechanisms. The total DNA damage combination with increased oxidative pressure and impaired mitochondria causes Alzheimer's disease as well as Parkinson's disease and schizophrenia. Pollutants and heavy metals increase psychiatric disorder risks when combined with genotoxic stress in the body which leads to neurodegeneration. The evaluation stresses the need to comprehend how DNA damage and repair functions work in biology because therapeutic methods which lower oxidative stress and boost DNA repair should provide better treatments for cognitive decline and brain health.
Keywords: Genotoxicity, neurodegeneration, oxidative stress, DNA repair