Natural Honey Beneficial to Health, Its Chemical Composition, and Biochemical Activities: A Review
Current Journal of Applied Science and Technology,
Page 1-14
DOI:
10.9734/cjast/2022/v41i423997
Abstract
Since early antiquity, honey has been utilized worldwide as a balanced meal and in supplementary treatment. It contains over 200 different substances, the majority of which are water, sugars, vitamins, enzymes, amino acids, minerals, and phytochemicals. It has health advantages, including microbial inhibition, healing, and its influence on other disorders. Additionally, it stimulates the immune system and helps immune cells mature. The nutritional value of honey is substantially influenced by the type of plants in the region, the climate, and the production process. Different types of honey were examined by various workers, they found a strong relationship between honey type and HMF, saccharose, and phenolic content, as well as acidity and antioxidant activity. For the level of vitamin C, glucose, and fructose, the combination of variety and manufacturing technique has a substantial influence. The focus of this study is on the biochemical processes and its potential health benefits. However, the precise mechanisms of honey's influence on many illnesses and activities have not yet been fully defined, and more study is necessary to understand their precise contributions.
Keywords:
- Honey
- composition
- antioxidants
- atherosclerosis
- inflammation
- immune system
How to Cite
Karapetkovska-Hristova, V., & Mustafa, S. K. (2022). Natural Honey Beneficial to Health, Its Chemical Composition, and Biochemical Activities: A Review. Current Journal of Applied Science and Technology, 41(42), 1-14. https://doi.org/10.9734/cjast/2022/v41i423997
References
Rao PV, Krishnan KT, Salleh N, Gan SH. Biological and therapeutic effects of honey produced by honey bees and stingless bees: a comparative review. Revista Brasileira de Farmacognosia, 2016; 26(5):657–664.
Fratellone PM, Tsimis F, Fratellone G. Apitherapy products for medicinal use. Journal of Alternative and Complementary Medicine. 2016;22(2):1020–1022.
Ajibola A. Physico-chemical and physiological values of honey and its importance as a functional food. International Journal of Food Sciences and Nutrition. 2015;2(6)1–9.
Alvarez-Suarez JM, Tulipani S, Romandini S, Bertoli E, Battino M. Contribution of honey in nutrition and human health: a review. Mediterranean Journal of Nutrition and Metabolism. 2010;3(1):15–23.
Molan PC. The role of honey in the management of wounds. Journal of Wound Care. 1999;8(8): 415–418.
Di Pasquale G, Salignon M, Le Conte Y et al. Influence of pollen nutrition on honey bee health: Do pollen quality and diversity matter? Plos One. 2013:e72016 Available:https://doi.org/10.1371/journal.pone.0072016
Janevski S. Prirodno lekuvanje so med. Martina komerc, Skopje; 2007.
Vahčić N, Matković D. Kemijske, fizikalne i senzorske značajke meda. URL; 2009. Available:https://dokumen.tips/download/link/kemijske-fizikalne-i-senzorske-karakteristike-meda (Accessed on 01.09.2018)
Primorac Lj, Angelkov B, Mandić LM, Kenjerić D, Nedeljko M, Flanjak I, Pirički PA, Arapceska M. Comparison of the Croatian and Macedonian honeydew honey. JCEA. 2009;10(3):263-270.
Ahmed М, Khiati B., Meslem A., Aissat, S. & Djebli, N. Evaluation of Physicochemical and Antioxidant Properties of Raw Honey from Algeria. J Microbial Biochem Technol. 2014;S4:006.
DOI:10.4172/1948-5948.S4-006
Hatjina F, Costa C, Büchler R et al. Population dynamics of European honey bee genotypes under different environmental conditions. Journal of Apicultural Research. 2014;53(233-247):23.
Maughan R. The athlete’s diet: Nutritional goals and dietary strategies. Proceedings of the Nutrition Society. 2002;61:87- 96.
Alvarez-Suarez J, Giampieri F, Battino M. Honey as a source of dietary antioxidants: structures, bioavailability and evidence of protective effects against human chronic diseases. Current Medicinal Chemistry. 2013;20:621-638.
Bogdanov S. Honey composition. The honey book. 2009;27-36.
Bogdanov S, Martin P. Honey authenticity. Mitteilungen aus Lebensmitteluntersuchung und Hygiene . 2002;93:232-254.
Bogdanov S, Ruoff K, Oddo LP. Physicochemical methods for the characterisation of unifloral honeys: A review. Apidologie. 2004;35:S4-S17.
Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. Journal of agricultural and food chemistry 2002; 50:3050- 3055.
Bogdanov S, Martin P. Honey authenticity. Mitteilungen aus Lebensmitteluntersuchung und Hygiene. 2002;93:232-254.
Bogdanov S, Ruoff K, Oddo LP. Physicochemical methods for the characterisation of unifloral honeys: A review. Apidologie. 2004;35:S4-S17.
Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of In vitro lipoprotein oxidation in human serum samples. Journal of Agricultural and Food Chemistry. 2002; 50:3050- 3055.
Mattoon WR. The southern cypress (No. 272). US Department of Agriculture; 1915.
Aili SR, Touchard A, Escoubas P et al. Diversity of peptide toxins from stinging ant venoms. Toxicon. 2014;92:166-178.
Ensminger ME, Ensminger AH. Foods & Nutrition Encyclopedia, Two Volume Set. CRC press.
Marın F, Martinez M, Uribesalgo T, Castillo S, M. Frutos. Changes in nutraceutical composition of lemon juices according to different industrial extraction systems. Food Chemistry. 2002;78(3) :319–324,.
Küçük M, Kolaylı S, Karaoğlu Ş, Ulusoy E, Baltacı C, Candan F. Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chemistry. 2002;100(2):526–534.
Biesalski HK, Dragsted LO, Elmadfa I et al. Bioactive compounds: Definition and assessment of activity. Nutrition. 2009; 25(11):1202–1205.
Moniruzzaman M, Khalil M, Sulaiman S, Gan S. Advances in the analytical methods for determining the antioxidant properties of honey: A review. African Journal of Traditional, Complementary and Alternative Medicines. 2012;9(1):36–42.
Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: A review. J. Am. Coll. Nutr. 2013; 27:677–689.
[CrossRef]
Balasundram N, Sundram K, Samman S. Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chem. 2006;99:191–203. [CrossRef]
Teixeira J, Gaspar A, Garrido EM, Garrido J, Borges F. Hydroxycinnamic acid antioxidants: An electrochemical overview. BioMed Res. Int. 2013:251754.
[CrossRef] [PubMed]
Hollman PCH, Katan MB. Dietary flavonoids: Intake, health effects and bioavailability. Food Chem. Toxicol. 1999; 37:937–942.
[CrossRef]
Procházková D, Boušová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia. 2011;82:513–523.
[CrossRef]
Tomas-Barberan FA, Martos I, Ferreres F, Radovic BS, Anklam E. HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys. J. Sci. Food Agric. 2001;81:485–496.
[CrossRef]
Yao L, Jiang Y, Singanusong R, D’Arcy B, Datta N, Caffin N, Raymont K. Flavonoids in Australian Melaleuca, Guioa, Lophostemon, Banksia and Helianthus honeys and their potential for floral authentication. Food Res. Int. 2004; 37:166–174.
[CrossRef]
Anklam E. A review of the analytical methods to determine the geographical and botanical origin of honey. Food Chem. 1998;63:549–562.
[CrossRef]
Yao L, Data N, Tomás-Barberán FA, Ferreres F, Martos I, Singanusong R. Flavonoids, phenolic acids and abscisic acid in Australian and New Zealand Leptospermum honeys. Food Chem. 2003;81:159–168.
[CrossRef]
Molan PC. The evidence supporting the use of honey as a wound dressing. The International Journal of Lower Extremity Wounds. 2006;5(1):40–54,.
Esmon CT. Crosstalk between inflammation and thrombosis. Maturitas. 2004;47(4):305–314.
Vermeulen H, Ubbink D, Goossens A, De Vos R, Legemate D. Systematic review of dressings and topical agents for surgical wounds healing by secondary intention. British Journal of Surgery. 2005;92(6): 665–672.
Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998;24(2):157–161.
Cooper R, Gray D. The control of wound malodour with honey-based wound dressings and ointments. Wounds UK, Aberdeen. 2005;26–32
White R, Molan P. A summary of published clinical research on honey in wound management. Honey: A modern wound management product. Wounds UK, Aberdeen. 2005;130–143.
Molan P. Why honey is effective as a medicine: 2. The scientific explanation of its effects. Bee World. 2001;82(1):22–40.
Aminu S, Hassan A, Babayo U. Another use of honey. Tropical Doctor. 2000;30(4):250–251.
Al-Waili NS. Topical application of natural honey, beeswax and olive oil mixture for atopic dermatitis or psoriasis: Partially controlled, single-blinded study. Complementary Therapies in Medicine. 2003;11(4):226–234.
Anyanechi C, B Saheeb. Honey and wound dehiscence: A study of surgical wounds in the mandibular bed. Nigerian Journal of Clinical Practice. 2015; 18(2):251–255.
S. Eick, G. Schäfer, J. Kwiecinski, J. Atrott, T. Henle, and W. Pfister, “Honey–a potential agent against Porphyromonas gingivalis: An In vitro study. BMC Oral Health. 2014;14(1)24.
Halim DS, Mahanani ES, Saini R, Omar M, Rubiantee bt Ibrahi N, Alam MK. A comparison study on the effectiveness of local honey and salicylate gel for treatment of minor recurrent aphtous stomatitis. International Medical Journal. 2013; 20(6):770–772.
JJ Song, P. Twumasi-Ankrah, and R. Salcido, “Systematic review and meta-analysis on the use of honey to protect from the effects of radiation-induced oral mucositis. Advances in Skin & Wound Care. 2012;25(1):23–28.
Sterer N, Rosenberg M. Breath Odors: Origin, Diagnosis, and Management, Springer Science & Business Media; 2011.
Shiga H, Jo A, Terao K, Nakano M, Oshima T, Maeda N. Decrease of halitosis by intake of Manuka honey. General Session of IADR Barcelona. 2010;14.
Ajibola A, Chamunorwa JP, Erlwanger KH. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutrition & Metabolism. 2012; 9(1):61.
Adebolu T. Effect of natural honey on local isolates of diarrhea-causing bacteria in southwestern Nigeria. African Journal of Biotechnology. 2005;4(10):1172.
Abeshu MA, Geleta B. Medicinal uses of honey. Biology and Medicine. 2016;8(2):1–7.
S. Kajiwara, H. Gandhi, and Z. Ustunol. Effect of honey on the growth of and acid production by human intestinal Bifidobacterium spp.: An In vitro comparison with commercial oligosaccharides and inulin. Journal of Food Protection®. 2002;65(1):214–218.
T. Shamala, Y. Shri Jyothi, and P. Saibaba. Stimulatory effect of honey on multiplication of lactic acid bacteria under in vitro and in vivo conditions. Letters in Applied Microbiology. 2000;30 (6):453–455.
Cardarelli HR, Buriti FC, Castro IA, Saad SM. Inulin and oligofructose improve sensory quality and increase the probiotic viable count in potentially synbiotic petit-suisse cheese. LWT-Food Science and Technology. 2008;41(6):1037–1046.
Header E, Hashish AEM, ElSawy N, Al-Kushi A, El-Boshy M. Gastroprotective effects of dietary honey against acetylsalicylate induced experimental gastric ulcer in albino rats. Life Science Journal. 2016;13:1.
Lychkova A, Kasyanenko V, Puzikov A. Gastroprotective effect of honey and bee pollen. Experimental & Clinical Gastroenterology. 2014;9:72.
Abdellah F, Abderrahim LA. 8 honey for gastrointestinal. In Honey in Traditional and Modern Medicine. CRC Press, Boca raton, Florida, USA. 2013;159.
Brandt LJ, Prather CM, Quigley EM, Schiller LR, Schoenfeld P, Talley NJ. Systematic review on the management of chronic constipation in North America. The American Journal of Gastroenterology. 2005;100:S1:S5–S21.
Andualem B. Synergistic antimicrobial effect of Tenegn honey (Trigona iridipennis) and garlic against standard and clinical pathogenic bacterial isolates. International Journal of Microbiology Research. 2013;4(1):L16–22.
S Zhang, T Jiao, Y. Chen, N. Gao, L. Zhang, and M. Jiang. Methylglyoxal induces systemic symptoms of irritable bowel syndrome. Plos One. 2014; 9(8).Article e105307.
Bessen DE. Tissue tropisms in group a streptococcus: What virulence factors distinguish pharyngitis from impetigo strains? Current Opinion in Infectious Diseases. 2016;29(3):295–303.
Gupta RK, S. Stangaciu. Apitherapy: Holistic healing through the honeybee and bee products in countries with poor healthcare system. In Beekeeping for Poverty Alleviation and Livelihood Security. Springer. 2014;413–446.
S. Patel, S. Cichello. Manuka honey: An emerging natural food with medicinal use. Natural Products and Bioprospecting. 2013;3(4):121–128.
Shadkam MN, Mozaffari-Khosravi H, Mozayan MR. A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. The Journal of Alternative and Complementary Medicine. 2010;16(7): 787–793.
Memon KN, Shaikh K, Pandhiani BS, Usman G. How do mothers recognize & treat pneumonia in their children at home? A study in union council Jhudo, District Mirpurkhas. Journal of Liaquat University of Medical & Health Sciences. 2013; 12(03)208.
Rakha MK, Nabil ZI, Hussein AA. Cardioactive and vasoactive effects of natural wild honey against cardiac malperformance induced by hyperadrenergic activity. Journal of Medicinal Food. 2008;11(1):91–98.
R. Afroz, E. Tanvir, N. Karim et al. Sundarban honey confers protection against isoproterenol-induced myocardial infarction in Wistar rats,” BioMed Research International. 2016;2016:10
Article ID:6437641.
M. Khalil S. Sulaiman, and L. Boukraa. Antioxidant properties of honey and its role in preventing health disorder,” The Open Nutraceuticals Journal. 2010;3(1):6–16.
A. Ajibola. Growth and metabolic response of suckling rats fed with natural honey supplements. Ommega Internations. 2016;3(1):1–8.
Daleprane JB, da Silva Freitas V, Pacheco A et al. Antiatherogenic and anti-angiogenic activities of polyphenols from propolis. The Journal of Nutritional Biochemistry. 2012;23(6): 557–566.
Bogdanov S, Jurendic T, Sieber R, P Gallmann. Honey for nutrition and health: A review. Journal of the American College of Nutrition. 2008;27(6):677–689.
Halligan E, Edgeworth J, Bisnauthsing K et al. Multiplex molecular testing for management of infectious gastroenteritis in a hospital setting: a comparative diagnostic and clinical utility study. Clinical Microbiology and Infection. 2014;20(8): O460–O467.
Abdulrhman MA, Mekawy MA, Awadalla MM, Mohamed AH. Bee honey added to the oral rehydration solution in treatment of gastroenteritis in infants and children. Journal of Medicinal Food. 2010;13(3): L605–609.
V. Falanga. Wound healing and its impairment in the diabetic foot. The Lancet. 2005;366(9498):1736–1743.
C. Dunford and R. Hanano. Acceptability to patients of a honey dressing for non-healing venous leg ulcers. Journal of Wound Care. 2004;13(5):193–198.
Mohamed H, Salma MA, Al Lenjawi B et al. Enhancing primary healing post ray amputation in a diabetic patient: Efficacy of natural honey. Journal of Diabetic Foot Complications. 2014;6(1): 13–18.
Wang Y, Li N. Cheng D et al. Antioxidant and hepatoprotective activity of Vitex honey against paracetamol induced liver damage in mice,” Food & Function. 2015;6(7):2339–2349.
Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh MM and Gurtu S. Antioxidant protection of Malaysian Tualang honey in pancreas of normal and streptozotocininduced diabetic rats. In Annales d'endocrinologie. Elsevier. 2010; 291–296.
Erejuwa OO, Sulaiman SA, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Glibenclamide or metformin combined with honey improves glycemic control in streptozotocininduced diabetic rats. International Journal of Biological Sciences. 2011;7(2):244–252.
Erejuwa OO, Sulaiman SA, Wahab MSA Effects of honey and its mechanisms of action on the development and progression of cancer. Molecules. 2011;19 (2):2497–2522,2014.
Wen CTP, Hussein SZ, Abdullah S, Karim NA, Makpo Sl, Yusof YAM. Gelam and Nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation. Asian Pacific Journal of Cancer Prevention. 2012;13(4):1605–1610.
S. Jaganathan, M. Mandal. Honey constituents and its apoptotic effect in colon cancer cells. Journal of Apiproduct and Apimedical Science. 2009;1(2):29– 36.
Abdel Aziz A, Rady H, Amer M, Kiwan H. Effect of some honey bee extracts on the proliferation, proteolytic and gelatinolytic activities of the hepatocellular carcinoma Hepg2 cell line. Australian Journal of Basic and Applied Science. 2009;3(3):2754–2769.
Germain D. Estrogen carcinogenesis in breast cancer,” Endocrinology and Metabolism Clinics of North America. 2011;40(3):473–484.
Tsiapara AV, Jaakkola M, Chinou I et al. Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts. Food Chemistry. 2009;116(3):702–708.
AN. Fauzi MN. Norazmi, Yaacob NS. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food and Chemical Toxicology. 2011;49(4):871– 878.
S. Ahmed and N. H. Othman. Honey as a potential natural anticancer agent: a review of its mechanisms. EvidenceBased Complementary and Alternative Medicine. 2013;2013:7.
Article ID 829070.
Syed Khalid Mustafa, Atif Abdul Wahab A. Oyouni, Meshari M.H. Aljohani1 and M. Ayaz Ahmad. Polyphenols more than an Antioxidant: Role and Scope. J. Pure Appl. Microbiol. 2020;14(1):47-61.
Syed Khalid Mustafa. COVID 19 and human immune function: the chemistryof vitamin - D. Egyptian Journal of Chemistry. 2022;65(1)555-564.
DOI:10.21608/EJCHEM.2021.82501.4064
Biljana Bogdanova Popov, Vesna Karapetkovska -Hristova, Stefce Presilski, Mohhamad Ali Shariati, Stevo Najman. Assesment of heavy metals in propolis and soil from Pelagonia region, Republic of Macedonia. Macedonian Journal of Chemistry and Chemical Engineering. 2017; 36(1):23-33.
Biljana Bogdanova Popov, Vesna Karapetkovska – Hristova et al. The use of natural bee products as bioindicators of environmental pollution-The Detection of Heavy Metals, Oriental Journal of Chemistry. 2022;38(1):28-36.
Daniel Ingo Hefft, Vesna Karapetkovska–Hristova, Naco Jovcevski. Traditional beekeeping Methods of North Macedonia, Bee World; 2022.
DOI: 10.1080/0005772X.2022.2035062
Available:https://www.tandfonline.com/doi/full/10.1080/0005772X.2022.2035062?src=
Fratellone PM, Tsimis F, Fratellone G. Apitherapy products for medicinal use. Journal of Alternative and Complementary Medicine. 2016;22(2):1020–1022.
Ajibola A. Physico-chemical and physiological values of honey and its importance as a functional food. International Journal of Food Sciences and Nutrition. 2015;2(6)1–9.
Alvarez-Suarez JM, Tulipani S, Romandini S, Bertoli E, Battino M. Contribution of honey in nutrition and human health: a review. Mediterranean Journal of Nutrition and Metabolism. 2010;3(1):15–23.
Molan PC. The role of honey in the management of wounds. Journal of Wound Care. 1999;8(8): 415–418.
Di Pasquale G, Salignon M, Le Conte Y et al. Influence of pollen nutrition on honey bee health: Do pollen quality and diversity matter? Plos One. 2013:e72016 Available:https://doi.org/10.1371/journal.pone.0072016
Janevski S. Prirodno lekuvanje so med. Martina komerc, Skopje; 2007.
Vahčić N, Matković D. Kemijske, fizikalne i senzorske značajke meda. URL; 2009. Available:https://dokumen.tips/download/link/kemijske-fizikalne-i-senzorske-karakteristike-meda (Accessed on 01.09.2018)
Primorac Lj, Angelkov B, Mandić LM, Kenjerić D, Nedeljko M, Flanjak I, Pirički PA, Arapceska M. Comparison of the Croatian and Macedonian honeydew honey. JCEA. 2009;10(3):263-270.
Ahmed М, Khiati B., Meslem A., Aissat, S. & Djebli, N. Evaluation of Physicochemical and Antioxidant Properties of Raw Honey from Algeria. J Microbial Biochem Technol. 2014;S4:006.
DOI:10.4172/1948-5948.S4-006
Hatjina F, Costa C, Büchler R et al. Population dynamics of European honey bee genotypes under different environmental conditions. Journal of Apicultural Research. 2014;53(233-247):23.
Maughan R. The athlete’s diet: Nutritional goals and dietary strategies. Proceedings of the Nutrition Society. 2002;61:87- 96.
Alvarez-Suarez J, Giampieri F, Battino M. Honey as a source of dietary antioxidants: structures, bioavailability and evidence of protective effects against human chronic diseases. Current Medicinal Chemistry. 2013;20:621-638.
Bogdanov S. Honey composition. The honey book. 2009;27-36.
Bogdanov S, Martin P. Honey authenticity. Mitteilungen aus Lebensmitteluntersuchung und Hygiene . 2002;93:232-254.
Bogdanov S, Ruoff K, Oddo LP. Physicochemical methods for the characterisation of unifloral honeys: A review. Apidologie. 2004;35:S4-S17.
Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. Journal of agricultural and food chemistry 2002; 50:3050- 3055.
Bogdanov S, Martin P. Honey authenticity. Mitteilungen aus Lebensmitteluntersuchung und Hygiene. 2002;93:232-254.
Bogdanov S, Ruoff K, Oddo LP. Physicochemical methods for the characterisation of unifloral honeys: A review. Apidologie. 2004;35:S4-S17.
Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of In vitro lipoprotein oxidation in human serum samples. Journal of Agricultural and Food Chemistry. 2002; 50:3050- 3055.
Mattoon WR. The southern cypress (No. 272). US Department of Agriculture; 1915.
Aili SR, Touchard A, Escoubas P et al. Diversity of peptide toxins from stinging ant venoms. Toxicon. 2014;92:166-178.
Ensminger ME, Ensminger AH. Foods & Nutrition Encyclopedia, Two Volume Set. CRC press.
Marın F, Martinez M, Uribesalgo T, Castillo S, M. Frutos. Changes in nutraceutical composition of lemon juices according to different industrial extraction systems. Food Chemistry. 2002;78(3) :319–324,.
Küçük M, Kolaylı S, Karaoğlu Ş, Ulusoy E, Baltacı C, Candan F. Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chemistry. 2002;100(2):526–534.
Biesalski HK, Dragsted LO, Elmadfa I et al. Bioactive compounds: Definition and assessment of activity. Nutrition. 2009; 25(11):1202–1205.
Moniruzzaman M, Khalil M, Sulaiman S, Gan S. Advances in the analytical methods for determining the antioxidant properties of honey: A review. African Journal of Traditional, Complementary and Alternative Medicines. 2012;9(1):36–42.
Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: A review. J. Am. Coll. Nutr. 2013; 27:677–689.
[CrossRef]
Balasundram N, Sundram K, Samman S. Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chem. 2006;99:191–203. [CrossRef]
Teixeira J, Gaspar A, Garrido EM, Garrido J, Borges F. Hydroxycinnamic acid antioxidants: An electrochemical overview. BioMed Res. Int. 2013:251754.
[CrossRef] [PubMed]
Hollman PCH, Katan MB. Dietary flavonoids: Intake, health effects and bioavailability. Food Chem. Toxicol. 1999; 37:937–942.
[CrossRef]
Procházková D, Boušová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia. 2011;82:513–523.
[CrossRef]
Tomas-Barberan FA, Martos I, Ferreres F, Radovic BS, Anklam E. HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys. J. Sci. Food Agric. 2001;81:485–496.
[CrossRef]
Yao L, Jiang Y, Singanusong R, D’Arcy B, Datta N, Caffin N, Raymont K. Flavonoids in Australian Melaleuca, Guioa, Lophostemon, Banksia and Helianthus honeys and their potential for floral authentication. Food Res. Int. 2004; 37:166–174.
[CrossRef]
Anklam E. A review of the analytical methods to determine the geographical and botanical origin of honey. Food Chem. 1998;63:549–562.
[CrossRef]
Yao L, Data N, Tomás-Barberán FA, Ferreres F, Martos I, Singanusong R. Flavonoids, phenolic acids and abscisic acid in Australian and New Zealand Leptospermum honeys. Food Chem. 2003;81:159–168.
[CrossRef]
Molan PC. The evidence supporting the use of honey as a wound dressing. The International Journal of Lower Extremity Wounds. 2006;5(1):40–54,.
Esmon CT. Crosstalk between inflammation and thrombosis. Maturitas. 2004;47(4):305–314.
Vermeulen H, Ubbink D, Goossens A, De Vos R, Legemate D. Systematic review of dressings and topical agents for surgical wounds healing by secondary intention. British Journal of Surgery. 2005;92(6): 665–672.
Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998;24(2):157–161.
Cooper R, Gray D. The control of wound malodour with honey-based wound dressings and ointments. Wounds UK, Aberdeen. 2005;26–32
White R, Molan P. A summary of published clinical research on honey in wound management. Honey: A modern wound management product. Wounds UK, Aberdeen. 2005;130–143.
Molan P. Why honey is effective as a medicine: 2. The scientific explanation of its effects. Bee World. 2001;82(1):22–40.
Aminu S, Hassan A, Babayo U. Another use of honey. Tropical Doctor. 2000;30(4):250–251.
Al-Waili NS. Topical application of natural honey, beeswax and olive oil mixture for atopic dermatitis or psoriasis: Partially controlled, single-blinded study. Complementary Therapies in Medicine. 2003;11(4):226–234.
Anyanechi C, B Saheeb. Honey and wound dehiscence: A study of surgical wounds in the mandibular bed. Nigerian Journal of Clinical Practice. 2015; 18(2):251–255.
S. Eick, G. Schäfer, J. Kwiecinski, J. Atrott, T. Henle, and W. Pfister, “Honey–a potential agent against Porphyromonas gingivalis: An In vitro study. BMC Oral Health. 2014;14(1)24.
Halim DS, Mahanani ES, Saini R, Omar M, Rubiantee bt Ibrahi N, Alam MK. A comparison study on the effectiveness of local honey and salicylate gel for treatment of minor recurrent aphtous stomatitis. International Medical Journal. 2013; 20(6):770–772.
JJ Song, P. Twumasi-Ankrah, and R. Salcido, “Systematic review and meta-analysis on the use of honey to protect from the effects of radiation-induced oral mucositis. Advances in Skin & Wound Care. 2012;25(1):23–28.
Sterer N, Rosenberg M. Breath Odors: Origin, Diagnosis, and Management, Springer Science & Business Media; 2011.
Shiga H, Jo A, Terao K, Nakano M, Oshima T, Maeda N. Decrease of halitosis by intake of Manuka honey. General Session of IADR Barcelona. 2010;14.
Ajibola A, Chamunorwa JP, Erlwanger KH. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutrition & Metabolism. 2012; 9(1):61.
Adebolu T. Effect of natural honey on local isolates of diarrhea-causing bacteria in southwestern Nigeria. African Journal of Biotechnology. 2005;4(10):1172.
Abeshu MA, Geleta B. Medicinal uses of honey. Biology and Medicine. 2016;8(2):1–7.
S. Kajiwara, H. Gandhi, and Z. Ustunol. Effect of honey on the growth of and acid production by human intestinal Bifidobacterium spp.: An In vitro comparison with commercial oligosaccharides and inulin. Journal of Food Protection®. 2002;65(1):214–218.
T. Shamala, Y. Shri Jyothi, and P. Saibaba. Stimulatory effect of honey on multiplication of lactic acid bacteria under in vitro and in vivo conditions. Letters in Applied Microbiology. 2000;30 (6):453–455.
Cardarelli HR, Buriti FC, Castro IA, Saad SM. Inulin and oligofructose improve sensory quality and increase the probiotic viable count in potentially synbiotic petit-suisse cheese. LWT-Food Science and Technology. 2008;41(6):1037–1046.
Header E, Hashish AEM, ElSawy N, Al-Kushi A, El-Boshy M. Gastroprotective effects of dietary honey against acetylsalicylate induced experimental gastric ulcer in albino rats. Life Science Journal. 2016;13:1.
Lychkova A, Kasyanenko V, Puzikov A. Gastroprotective effect of honey and bee pollen. Experimental & Clinical Gastroenterology. 2014;9:72.
Abdellah F, Abderrahim LA. 8 honey for gastrointestinal. In Honey in Traditional and Modern Medicine. CRC Press, Boca raton, Florida, USA. 2013;159.
Brandt LJ, Prather CM, Quigley EM, Schiller LR, Schoenfeld P, Talley NJ. Systematic review on the management of chronic constipation in North America. The American Journal of Gastroenterology. 2005;100:S1:S5–S21.
Andualem B. Synergistic antimicrobial effect of Tenegn honey (Trigona iridipennis) and garlic against standard and clinical pathogenic bacterial isolates. International Journal of Microbiology Research. 2013;4(1):L16–22.
S Zhang, T Jiao, Y. Chen, N. Gao, L. Zhang, and M. Jiang. Methylglyoxal induces systemic symptoms of irritable bowel syndrome. Plos One. 2014; 9(8).Article e105307.
Bessen DE. Tissue tropisms in group a streptococcus: What virulence factors distinguish pharyngitis from impetigo strains? Current Opinion in Infectious Diseases. 2016;29(3):295–303.
Gupta RK, S. Stangaciu. Apitherapy: Holistic healing through the honeybee and bee products in countries with poor healthcare system. In Beekeeping for Poverty Alleviation and Livelihood Security. Springer. 2014;413–446.
S. Patel, S. Cichello. Manuka honey: An emerging natural food with medicinal use. Natural Products and Bioprospecting. 2013;3(4):121–128.
Shadkam MN, Mozaffari-Khosravi H, Mozayan MR. A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. The Journal of Alternative and Complementary Medicine. 2010;16(7): 787–793.
Memon KN, Shaikh K, Pandhiani BS, Usman G. How do mothers recognize & treat pneumonia in their children at home? A study in union council Jhudo, District Mirpurkhas. Journal of Liaquat University of Medical & Health Sciences. 2013; 12(03)208.
Rakha MK, Nabil ZI, Hussein AA. Cardioactive and vasoactive effects of natural wild honey against cardiac malperformance induced by hyperadrenergic activity. Journal of Medicinal Food. 2008;11(1):91–98.
R. Afroz, E. Tanvir, N. Karim et al. Sundarban honey confers protection against isoproterenol-induced myocardial infarction in Wistar rats,” BioMed Research International. 2016;2016:10
Article ID:6437641.
M. Khalil S. Sulaiman, and L. Boukraa. Antioxidant properties of honey and its role in preventing health disorder,” The Open Nutraceuticals Journal. 2010;3(1):6–16.
A. Ajibola. Growth and metabolic response of suckling rats fed with natural honey supplements. Ommega Internations. 2016;3(1):1–8.
Daleprane JB, da Silva Freitas V, Pacheco A et al. Antiatherogenic and anti-angiogenic activities of polyphenols from propolis. The Journal of Nutritional Biochemistry. 2012;23(6): 557–566.
Bogdanov S, Jurendic T, Sieber R, P Gallmann. Honey for nutrition and health: A review. Journal of the American College of Nutrition. 2008;27(6):677–689.
Halligan E, Edgeworth J, Bisnauthsing K et al. Multiplex molecular testing for management of infectious gastroenteritis in a hospital setting: a comparative diagnostic and clinical utility study. Clinical Microbiology and Infection. 2014;20(8): O460–O467.
Abdulrhman MA, Mekawy MA, Awadalla MM, Mohamed AH. Bee honey added to the oral rehydration solution in treatment of gastroenteritis in infants and children. Journal of Medicinal Food. 2010;13(3): L605–609.
V. Falanga. Wound healing and its impairment in the diabetic foot. The Lancet. 2005;366(9498):1736–1743.
C. Dunford and R. Hanano. Acceptability to patients of a honey dressing for non-healing venous leg ulcers. Journal of Wound Care. 2004;13(5):193–198.
Mohamed H, Salma MA, Al Lenjawi B et al. Enhancing primary healing post ray amputation in a diabetic patient: Efficacy of natural honey. Journal of Diabetic Foot Complications. 2014;6(1): 13–18.
Wang Y, Li N. Cheng D et al. Antioxidant and hepatoprotective activity of Vitex honey against paracetamol induced liver damage in mice,” Food & Function. 2015;6(7):2339–2349.
Erejuwa O, Sulaiman S, Wahab M, Sirajudeen K, Salleh MM and Gurtu S. Antioxidant protection of Malaysian Tualang honey in pancreas of normal and streptozotocininduced diabetic rats. In Annales d'endocrinologie. Elsevier. 2010; 291–296.
Erejuwa OO, Sulaiman SA, Wahab M, Sirajudeen K, Salleh M, Gurtu S. Glibenclamide or metformin combined with honey improves glycemic control in streptozotocininduced diabetic rats. International Journal of Biological Sciences. 2011;7(2):244–252.
Erejuwa OO, Sulaiman SA, Wahab MSA Effects of honey and its mechanisms of action on the development and progression of cancer. Molecules. 2011;19 (2):2497–2522,2014.
Wen CTP, Hussein SZ, Abdullah S, Karim NA, Makpo Sl, Yusof YAM. Gelam and Nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation. Asian Pacific Journal of Cancer Prevention. 2012;13(4):1605–1610.
S. Jaganathan, M. Mandal. Honey constituents and its apoptotic effect in colon cancer cells. Journal of Apiproduct and Apimedical Science. 2009;1(2):29– 36.
Abdel Aziz A, Rady H, Amer M, Kiwan H. Effect of some honey bee extracts on the proliferation, proteolytic and gelatinolytic activities of the hepatocellular carcinoma Hepg2 cell line. Australian Journal of Basic and Applied Science. 2009;3(3):2754–2769.
Germain D. Estrogen carcinogenesis in breast cancer,” Endocrinology and Metabolism Clinics of North America. 2011;40(3):473–484.
Tsiapara AV, Jaakkola M, Chinou I et al. Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts. Food Chemistry. 2009;116(3):702–708.
AN. Fauzi MN. Norazmi, Yaacob NS. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food and Chemical Toxicology. 2011;49(4):871– 878.
S. Ahmed and N. H. Othman. Honey as a potential natural anticancer agent: a review of its mechanisms. EvidenceBased Complementary and Alternative Medicine. 2013;2013:7.
Article ID 829070.
Syed Khalid Mustafa, Atif Abdul Wahab A. Oyouni, Meshari M.H. Aljohani1 and M. Ayaz Ahmad. Polyphenols more than an Antioxidant: Role and Scope. J. Pure Appl. Microbiol. 2020;14(1):47-61.
Syed Khalid Mustafa. COVID 19 and human immune function: the chemistryof vitamin - D. Egyptian Journal of Chemistry. 2022;65(1)555-564.
DOI:10.21608/EJCHEM.2021.82501.4064
Biljana Bogdanova Popov, Vesna Karapetkovska -Hristova, Stefce Presilski, Mohhamad Ali Shariati, Stevo Najman. Assesment of heavy metals in propolis and soil from Pelagonia region, Republic of Macedonia. Macedonian Journal of Chemistry and Chemical Engineering. 2017; 36(1):23-33.
Biljana Bogdanova Popov, Vesna Karapetkovska – Hristova et al. The use of natural bee products as bioindicators of environmental pollution-The Detection of Heavy Metals, Oriental Journal of Chemistry. 2022;38(1):28-36.
Daniel Ingo Hefft, Vesna Karapetkovska–Hristova, Naco Jovcevski. Traditional beekeeping Methods of North Macedonia, Bee World; 2022.
DOI: 10.1080/0005772X.2022.2035062
Available:https://www.tandfonline.com/doi/full/10.1080/0005772X.2022.2035062?src=
-
Abstract View: 264 times
PDF Download: 43 times
