Design, Synthesis and Biological Activities of Some phthalimides Derivatives
F. O. Taiwo *
Department of Chemistry, Obafemi Awolowo University. Nigeria.
C. A. Obafemi
Department of Chemistry, Obafemi Awolowo University. Nigeria.
E. M. Obuotor
Department of Biochemistry and Molecular Biology, Obafemi Awolowo University. Nigeria.
I. J. Olawuni
Department of Biochemistry and Molecular Biology, Obafemi Awolowo University. Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible biological properties.
Methods: The substituted phenylisoindoline-1,3-dione were synthesized from the reactions of N-phenyl phthalimide with different substituted aromatic aldehyde. The synthesized compounds were characterized using nuclear magnetic resonance spectroscopic analysis. The Nitric oxide and Ferric reducing antioxidant properties (FRAP) were determined by spectrophochemical method.
Results: The IC50 values for all the synthesized compounds were lower than standard, eserine (IC50 = 15 ± 2 µg/mL) against Nitric oxide inhibition. Compounds 3 (FRAP = 205±8 µg/ML) and 6 (FRAP = 118±1 µg/ML) were found to exhibit higher FRAP analysis results which were comparable to the results obtained for serine. (FRAP = 202±7 µg/ML).
Conclusion: The considerable activity of the compounds shown by its Nitric oxide and Ferric reducing antioxidant properties (FRAP) makes them good candidates for the development of selective acetylcholinesterase and butyryl cholinesterase inhibitors.
Keywords: Eserine, chalcones, Nitric oxide, Ferric reducing antioxidant Nitric oxide, Ferric reducing antioxidant properties