Review on Pharmacological Profile of Medicinal Vine: Tinospora cordifolia

Main Article Content

Kumar Antul
Paul Amandeep
Singh Gurwinder
Choudhary Anuj

Abstract

Tinospora is highly distributed in the tropical and subtropical region of India. This climbing deciduous shrub widely reported in China, Bangladesh and Srilanka. The plant is rich in many phytoconstituents that are useful in drug designing. It is highly used against cancer, tumour suppression, and act as an anti-allergic compound. It is commonly known as gudhuchi, belongs to the family Menispermeaceae. Tinospora is most valuable herb known for its medicinal properties from Vedic periods and cures various diseases such as malaria, asthma and urinary disorders. The genus Tinospora consists of many classes of chemicals such as alkaloids, diterpenoids lactones, steroids, aliphatic compounds and polysaccharides. It is the best remedy for both children as well as adults against respiratory tract diseases. The plant shows various antioxidant, anti-hyperglycemic, anti-neoplastic and hepatoprotective properties. In this review article medicinal property, chemical constituents and full description have been explored.

Keywords:
Tinospora, gudhuchi, diterpenoids, antioxidant, anti-neoplastic, steroids.

Article Details

How to Cite
Antul, K., Amandeep, P., Gurwinder, S., & Anuj, C. (2019). Review on Pharmacological Profile of Medicinal Vine: Tinospora cordifolia. Current Journal of Applied Science and Technology, 35(5), 1-11. https://doi.org/10.9734/cjast/2019/v35i530196
Section
Review Article

References

Raghu AV, Geetha SP, Martin G, Balachandran I, Ravindran PN. In vitro clonal propagation through mature nodes of Tinospora cordifolia (Willd.) Hook F, Thoms. An important ayurvedic medicinal plant. In vitro cell Dev Biol – Plant. 2006; 42:584-88.

Onkar P, Bangar J, Karodi R. Evaluation of antioxidant activity of traditional formulation Giloy satva and hydroalcoholic extract of the Curculigo orchioides gaertn). J App Pharm Sci. 2012;2(6):209-13.

Sangeetha MK, Priya CD, Vasanthi HR. Antidiabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes. Phytomedicine. 2013; 20(3-4):246-48.

Spandana U, Ali SL, Nirmala T, Santhi M, Sipai Babu SD. A review on Tinospora cordifolia. Int J Curr Pharm Rev Res. 2013; 4(2):61-8.

Singla A. Review of biological activities of “Tinospora cordifolia”. Webmed Cent Pharm Sci. 2010;1(9):WMC0060.

Sinha K, Mishr NP, Singh J, Khanuja SPS. Tinospora cordifolia, a reservoir plant for therapeutic application. Indian J Tradit Know. 2004;3(3):257-70.

Shetty BV, Singh V. Flora of Rajasthan. 1st edition, Merrut publishers and Distributors, Merrut. 2010;1:756-1000.

Singh J, Sinha K, Sharma A, Mishra NP, Khanuja SP. Traditional uses of Tinospora cordifolia (Guduchi). J Med Aromat Plant Sci. 2003;25:748–51.

Hossain MM, Hasan SMR, Akter R, Islam MN, Rashid MJ, Saha MR, et al. Evaluation of analgesic and neuropharmacological properties of the aerial part of Tinospora cordifolia Miers. in mice. S J Pharm Sci. 2009; 2(2):31-7.

Upadhyay AK, Kumar K, Kumar A, Mishra SH. Tinospora cordifolia (Wild.) Hook. f. and Thoms. (Guduchi)- validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res. 2010;1(2): 112–21.

Kavitha BT, Shruthi SD, Rai SP, Ramachandra YL. Phytochemical analysis and hepatoprotective properties of Tinospora cordifolia against carbon tetra-chloride induced hepatic damage in rats. J Basic Clin Pharm. 2011;2(3):139-42.

Dikshit V, Damre AS, Kulkarni KR, Gokhale A, Saraf MN. Preliminary screening of immunocin for immunemodu-latory activity. Indian J Pharm Sci. 2000;62:257.

Desai RV, Kamat JB, Sainis KB. An immunemodulator from Tinospora cordifolia with antioxidant activity in cell-free systems. J Chem Sci. 2012;114(6): 713-19.

Singh SS, Pandey SC, Srivastava S, Gupta VS, Patro B, Ghosh AC. Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Indian J Pharm. 2003; 35:83-91.

Pendse VK, Dadhich AP, Mathur PN, Madam MSB. Anti-inflammatory, immunosuppressive and some related pharmacological actions of the water extract of Neem Giloe (Tinospora cordifolia): A preliminary report. Indian J Pharm. 1977;9:221-24.

Neeraja PV, Margaret E. Amruthavalli (Tinospora cordifolia) multipurpose rejuvenator. Int J Pharm Biol Chem Sci. 2013;3(2):233-41.

Sharma PC, Yelne MB, Dennis TJ. Database on medicinal plants used in Ayurveda. Central council of research in Ayurveda & Siddha, New Delhi; 2005.

Rout GR. Identification of Tinospora cordifolia (Willd.) Miers ex Hook F & Thomas using RAPD markers. Z Natur for Sch C. 2006;61:118-22.

Patel SS, Shah RS, Goyal RK. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp Biol. 2009;47:564‑70.

Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine. 2011;18:1045- 52.

Ly PT, Singh S, Shaw CA. Novel environmental toxins: Steryl glycosides as a potential etiological factor for age‑related neurodegenerative diseases. J Neurosci Res. 2007;85:231-7.

Sengupta S, Mukherjee A, Goswami R, Basu S. Hypoglycemic activity of the antioxidant saponarin, characterized as alpha‑glucosidase inhibitor present in Tinospora cordifolia. J Enzyme Inhib Med Chem. 2009;24:684‑90.

Lv J, Xu D, Perkovic V, Ma X, Johnson DW, Woodward M, et al. Corticosteroid therapy in IgA nephropathy. J Am Soc Nephrol. 2012;23:1108-16.

Lee IA, Kim EJ, Kim DH. Inhibitory effect of β‑sitosterol on TNBS‑induce. Colitis in mice. Planta Med. 2012;78: 896‑8.

De Oliveira AM, Conserva LM, de Souza Ferro JN, de Almeida Brito F, Lyra Lemos RP, Barreto E. Antinociceptive and anti‑inflammatory effects of octacosanol from the leaves of Sabicea grisea var. Grisea in mice. Int J Mol Sci. 2012;13: 1598‑1611.

Taylor JC, Rapport L, Lockwood GB. Octacosanol in human health. Nutrition. 2003;19:192‑5.

Sriramaneni RN, Omar AZ, Ibrahim SM, Amirin S, Mohd Zaini A Vasorelaxant effect of diterpenoid lactones from Andrographis paniculata chloroform extract on rat aortic rings. Pharmacognosy Res. 2010;2:242- 6.

Dhanasekaran M, Baskar AA, Ignacimuthu S, Agastian P, Duraipandiyan V. Chemo-preventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine‑ induced hepatocellular carcinoma. Invest New Drugs. 2009;27: 347‑55.

Ghosh AK, Martyr CD, Steffey M, Wang YF, Agniswamy J, Amano M, et al. Design of substituted bis‑Tetrahydrofuran (bis- THF)‑derived potent HIV‑1 protease inhibitors, protein‑ligand X‑ray structure, and convenient syntheses of bis‑THF and Substituted bis‑THF Ligands. ACS Med Chem Lett. 2011;2:298- 302.

Mukherjee R, De UK, Ram GC. Evaluation of mammary gland immunity and therapeutic potential of Tinospora cordifolia against bovine subclinical mastitis. Trop Anim Health Prod. 2010;42:645‑51.

Upadhyaya R, PR, Sharma V, Anita KV. Assessment of the multifaceted immune-modulatory potential of the aqueous extract of Tinospora cordifolia. Res J Chem Sci. 2011;1:71‑9.

Sharma V, Pandey D. Beneficial effects of Tinospora cordifolia on blood profiles in male mice exposed to lead. Toxicol Int. 2010;17:8‑11.

Kalikar MV, Thawani VR, Varadpande UK, Sontakke SD, Singh RP, Khiyani RK. Immunomodulatory effect of Tinospora cordifolia extract in human immuno‑ deficiency virus positive patients. Indian J Pharmacol. 2008;40:107‑10.

Akhtar S. Use of Tinospora cordifolia in HIV infection. Indian J Pharmacol. 2010: 42:57.

Rao SK, Rao PS. Alteration in the radiosensitivity of HeLa cells by dichloromethane extract of guduchi (Tinospora cordifolia). Integr Cancer Ther. 2010;9:378-84.

GawhareVikesh S. A review on guduchi through Ayurvedic texts. International Ayurvedic Medical Journal. 2013;1(3):1- 7.

Pratibha Baghel. Plant of versatile properties: A review of Tinospora Cordifolia (Guduchi). International Journal of Agriculture Innovations and Research. 2017;5(5):751–753.

Saha S, Ghosh S. Tinospora cordifolia: One plant, many roles. Ancient Science of Life. 2012;31(4):151.

Sevindik M, Akgul H, Pehlivan M, Selamoglu Z. Determination of therapeutic potential of Mentha longifolia ssp. longifolia. Fresen Environ Bull. 2017;26: 4757-4763.

Pehlivan M, Mohammed FS, Sevindik M, Akgul H. Antioxidant and oxidant potential of Rosa canina. Eurasian Journal of Forest Science. 2018;6(4):22-25.